As of the start of the 2008 season, the Giants have the most franchise wins with 10,184. The Cubs are second with 9,985 franchise wins.
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Saint Louis Cardinals
Boston Red Sox
The San Francisco Giants have won the most games of any MLB franchise with an overall record of 10,184 wins 8,724 losses.
note the record for most wins by a team playing in the same city is held by the Chicago Cubs (10,091-9,531 as of April 27th 2009)
Through the 2010 season ...
1) Yankees with 40 - record is 27-13.
2) Giants and Dodgers with 18 - both teams have a record of 6-12.
4) Cardinals with 17 - record is 10-7.
5) Athletics with 14 - record is 9-5.
In 1935, the Chicago Cubs set the Major League Baseball record for consecutive wins with 21 wins in a row. The streak started on September 4, 1935 with an 8-2 victory over the Phillies and was snapped on September 28, 1935 with a 7-5 defeat to the Cardinals.