Babe Ruth hit career home run number 500 on August 11, 1929, in Cleveland off Indians pitcher Willis Hudin, in the top of the second inning.
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September 13, 1965 off Don Nottebart of the Houston Astros at the Astrodome in Houston.
Hank Aaron hit his 715th home run on April 8, 1974 against pitcher Al Downing of the Los Angeles Dodgers.