11 postions make up both the offensive and defensive teams. On Defense there are typically 2 safeties, 2 cornerbacks, 3 linebackers, and 4 denesive lineman. Some teams run variations of this such as the 3-4 defense where there are only 3 defensive lineman and 4 linebackers. Safeties and corners are considered Defensive backs so in a Nickle package there are 5 DB's instead of 4 things like that.
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1. Formation contains 11 players.
2. Every player should have a substitute.
That gives you 22 players at least.
3. Now, note that there's usually more than one substitute for a starter. An NFL team should actually handle 2-3 substitutes.
4. An average would be then: 33~44 defensive players per an NFL team.
In the college/high school 80-99. NFL 50-59, 90-99, 70-79. Although I play high school and sport #42 at D end