Any loss to Iowa State is arguably the worst loss ever.
Wisconsin
James Madison
chickens 87 Tigers 73 after the 2008-2009 season
33-11-2 Auburn leading and winning 13 in a row.
FSU destroys Michigan at Michigan. 51-31
1996 they lost to Ohio State 72-0.
In Bryant Denny Stadium: 1951 Villanova 41 - Alabama 18
130-0 vs Michigan on October 22, 1904.
For football: Auburn leads 26-21-3
The loss of dignity and innocence for the whole program in 2011. Or the 79 Sugar Bowl.
the worst loss for them is 9-0 to the boston bruins