Any loss to Iowa State is arguably the worst loss ever.
Wisconsin
James Madison
chickens 87 Tigers 73 after the 2008-2009 season
33-11-2 Auburn leading and winning 13 in a row.
FSU destroys Michigan at Michigan. 51-31
As of now, the worst football team in the league is subjective and can vary based on different factors such as win-loss record, performance, and statistics.
130-0 vs Michigan on October 22, 1904.
In Bryant Denny Stadium: 1951 Villanova 41 - Alabama 18
1996 they lost to Ohio State 72-0.
Missouri's worst loss in football occurred on October 31, 1975, when they were defeated by the University of Kansas with a score of 55-0. This game marked a significant low point for the program, as it was a humiliating defeat against their longstanding rival. The loss is often remembered as one of the most lopsided games in Missouri's football history.
For football: Auburn leads 26-21-3