#22 is used by Syracuse (one of the university powerhouses) as a number reserved for their greatest players. To anyone who follows university Lacrosse, #22 signifies many of the greats who have played the game, especially at Syracuse who just happened to wear it.... sort of like #99 in hockey always conjures up images of Wayne Gretzky. Over time, the number became synonimous with great players. Any ways, #22 is only given out to the best player on the team.
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It's just a squad number it doesn't mean anything. Though you may hear Arsenal fans praising the number 14 (Currently worn by Theo Walcott) because it used to be the number of Arsenal legend Thierry Henry, who is currently wearing the 14 for New York Redbulls
22 is the total number of players allowed on a soccer field at once. (11 per team)