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Nolan Ryan struck out a total of 16 batters in a single game against the Boston Red Sox on April 22, 1974, setting a record for the most strikeouts by a pitcher in a game at that time. Among the players he struck out, the notable one is Hall of Famer Reggie Jackson, who was one of Ryan's frequent strikeout victims throughout his career. In total, Ryan struck out Jackson 39 times, making him one of the top players struck out by Ryan.
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