Depends on what tournament they are.
For World Cup Qualifying, No.
For Quarterfinals, Semifinals, Final on tournament like the Gold Cup and the Champions Cup yes.
Confederation of North, Central American and Caribbean Association Football (Soccer).
None or up to 3. Depends on what the coach has done previously in the game. Soccer only allows 3 substitutions in any official game.
Tie breaker
In accordance with FIFA Laws of the Game "Kicks from the Penalty Mark" is a sanctioned method of determining the winner of a match after overtime periods have been played.
CONCACAF was created in 1961.
The US men's national soccer team has won the CONCACAF Gold Cup 6 times.
CONCACAF Gold Cup was created in 1991.
CONCACAF Champions League was created in 1962.
CONCACAF Championship was created on 1961-09-18.
CONCACAF Giants Cup happened in 2001.
CONCACAF's Women's Championship ended in 1998.
CONCACAF's Women's Championship was created in 1991.