He has like nine 50-point games as of the end of the 2010-2011 season. You can easily look up questions like this on http://www.thestatsace.com for all sports I think.
His last one was on February 3, 2011 and he had 51.
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Dwyane Wade scored 50 points or more only 3 times in his career. He scored 50 points against The Utah Jazz in the 2008-2009 season, again 50 against The Orlando Magic same season and 55 career high against The New York Knicks same season!!