The Colts and Giants never met in a Super Bowl. They did meet in "The Greatest Game Ever Played," the NFL Championship game of 1958, almost ten years before the first Super Bowl. The last Super Bowl the Giants played in was Super Bowl 42 in 2008. Eli Manning led the Giants to victory over the New England Patriots. The last Super Bowl the Colts played was the year before, when Peyton Manning (Eli's big brother) led the Colts to victory over the Chicago Bears.
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No, they have played against each other only twice and the Colts won both games. September 10, 2006 - the Colts beat the Giants 26-21 September 19, 2010 - the Colts beat the Giants 38-14
The Baltimore Colts won Super Bowl V with Johnny Unitas in 1971.
Through the 2008 regular season, once. That was September 10, 2006 when the Peyton and the Colts defeated Eli and the Giants, 26-21. Peyton completed 25 passes in 41 attempts for 276 yards, 1 TD, and 1 INT and Eli completed 20 passes in 34 attempts for 247 yards, 2 TDs, and 1 INT.
As of December 4, 2010, the Colts are not leading their division. They and the Jacksonville Jaguars both hold 6-5 records, but Jacksonville already owns a win over the Colts, and therefore has the tiebreaker. The colts are also currently trailing the Steelers by one game for the second wild card spot.
Both teams have won at least one Super Bowl to be clear. When they played against one another in the 2010 Super Bowl held in Miami, Florida the New Orleans Saints came out victorious. They beat the Indianapolis Colts 31-17.