The referee indicates that a game is over by blowing his whistle. Traditionally, referees will blow the whistle three times in a long-short-long pattern, which helps distinguish it from other whistles and sort-of has a more final, epic feeling to it.
Additionally, some referees will use a hand signal or gesture to accompany the final whistle. This is especially true for televised matches. Some referees will wave one or both hands above their head (think, "That's all, no more, stop!"), and/or point toward the center mark as they would for a kick-off, again using one hand, or more commonly, both hands.In very rare instances of riotous or dangerous conditions where the referee has lost control and cannot regain it, he may simply beckon his crew to exit the field, maybe blow a whistle, and get out of Dodge; referees are awesome, but they aren't superheroes and won't be standing in the middle of a field giving proper signals when things are being thrown at them.
A whistle is blown by a soccer referee to signal the ending of a soccer game.
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The only thing the ref does to end the game is he blows his whistle three times. There are no physical gestures done by the ref.
The referee blows one long blast on his whistle to signal the end of a football match in the UK.