Well I know that Tony Romo threw five vs. the Bills and they won. I think that was a tie for the most with a few other people hope I helped.
Rich Gannon.
Brett Favre - 366 interceptions in his career, regular season and playoffs.
As of October 2023, the record for the most interceptions thrown in a single NFL season is held by George Blanda, who threw 42 interceptions in 1962 while playing for the Oakland Raiders. This record still stands as one of the most infamous in NFL history, reflecting the challenges and risks associated with the passing game during that era.
Jim hardy threw 8 in 1950 for the Chicago cardinals (now Arizona)
In 2010, Eli Manning of the New York Giants threw the most interceptions with 25.
Jim hardy of the cardinals threw 8 interceptions in a game in the 1950's
Jay Cutler last year against the 49ers who had 6 interceptions; and they still almost won, but Cutler threw a interception on the last drive.
Rich Gannon.
danny wuefel
Brett Favre - 366 interceptions in his career, regular season and playoffs.
As of October 2023, the record for the most interceptions thrown in a single NFL season is held by George Blanda, who threw 42 interceptions in 1962 while playing for the Oakland Raiders. This record still stands as one of the most infamous in NFL history, reflecting the challenges and risks associated with the passing game during that era.
Jim hardy threw 8 in 1950 for the Chicago cardinals (now Arizona)
Jay Cutler!
In 1955, Jim Finks threw 26 interceptions, that was the most by a Steelers quarterback in one season.
In 2010, Eli Manning of the New York Giants threw the most interceptions with 25.
Through the 2008 season in the NFL, that is Brett Favre with 310 career interceptions.
There are actually four different quarterbacks who hold that record. Brett Farve, Frank Filchock, Bobby Layne and Norm Van Brocklin all threw 6 interceptions in a single playoff game.