Brett Favre - 366 interceptions in his career, regular season and playoffs.
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In 2010, Eli Manning of the New York Giants threw the most interceptions with 25.
Through the 2008 season in the NFL, that is Brett Favre with 310 career interceptions.
Rich Gannon.
Bret favre
Brett farve for a fact has thrown the most touchdowns. But I'm not sure if he threw the most interceptions as well