Rickey Henderson, playing for the San Diego Padres, in 2001.
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At the start of the 2008 season, the Rays team record for most runs scored in a game is 19 against the Yankees in 2006 and the Blue Jays in 2004. The Rays record for most runs scored in an inning is 11 against the Mariners in 2000.
Babe broke the record for career home runs, which was 138, in 1921 and broke the single season record for home runs in 1919 (record was 27 and he hit 29), 1920 (record was 29 and he hit 54), 1921 (record was 54 and he hit 59), and 1927 (record was 59 and he hit 60).
Barry Bonds broke the record in the 20 century.
Ever? The Chicago Cubs, who have scored 91,908 runs in their history. In a season? The 1931 Yankees, who scored 1,067 runs that year (record since 1901, records before then are wonky). In a game? 30, by the Texas Rangers, 8/22/2007
13 runs in the 4th inning April 13, 2003 at Cincinnati Reds.