A Pinch hit GRAND SLAM against the Colorado Rockies
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Although the definition of "major league" has been argued, present day MLB, as well as the Hall of Fame, define the first "major" league as the National League founded in 1876. The link below describes the first game played in that league, on April 22, and mentions that Jim O'Rourke got the first hit in that game.
Because the National League has been in existence longer than the American League ... the National League's first season as a major league was 1876 and the American League's first season as a major league was 1901.
The first Major League All-Star Game was played at Comiskey Park in Chicago, Illinois. The date was July 6, 1933 and the American League was the winner.
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Bumpus Jones of the Cincinnati Reds threw a no hitter on October 15, 1892 in his first major league game.