Phil Niekro.
Rose had 64 hits in 226 at bats against Niekro for a .283 batting average. The 226 at bats was also the most Rose had against any pitcher.
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Pete Rose got his 3000th base hit in his 2370th game on May 5, 1978 against the Montreal Expos and pitcher Steve Rogers.
Pete Rose had 4,256 hits during his career.
Most hits all TimeNameHitsRankPete Rose4,2561Ty Cobb4,1892Hank Aaron3,7713Stan Musial3,6304Tris Speaker3,5145Carl Yastrzemski3,4196Honus Wagner3,4157Paul Molitor3,3198Eddie Collins3,3159Willie Mays3,28310
Lou Gehrig's final at bat came in the 8th inning of the game against the Washington Senators on April 30, 1939. The pitcher was Pete Appleton and Lou flied out to center field.
Pete Rose's first game with the Cincinnati Reds came on April 8, 1963 against the Pittsburgh Pirates. The first pitcher he faced was Earl Francis and Rose drew a walk in the first inning (he was batting second in the order) and then scored on a Frank Robinson home run.