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The Record is Eight by the Atlanta Braves against the Florida Marlins on July 24,2010.

No sorry this answer is completely wrong. They scored 8 runs in one inning, not HOME RUNS...IDIOT!!!!!! The record is 5 done 5 times. So please get it strate

Get your answer straight

On July 4, 1977, the Boston Red Sox hit eight home runs against the Toronto Blue Jays. Seven of them were hit with nobody on base setting the Major League record for most home runs in a game with nobody on base.

On September 4, 1999, eight players from the Cincinnati Reds hit a home run in a game versus the Philadelphia Phillies setting a Major League record for most players with a home run during a game.

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