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Barry Sanders holds the NFL record for most runs over 50 yards (25 times) and most touchdown runs over 50 yards (15 times; next closest is Jim Brown with 12). Most websites also report runs of 20+ yards, however, this statistic was not regularly kept by the NFL until 2002, and Sanders retired in 1998.

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12y ago

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Emmitt Smith

http://www.pro-football-reference.com/players/S/SmitEm00.htm?redir

18355 Career Yards

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17y ago
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