Barry Sanders holds the NFL record for most runs over 50 yards (25 times) and most touchdown runs over 50 yards (15 times; next closest is Jim Brown with 12). Most websites also report runs of 20+ yards, however, this statistic was not regularly kept by the NFL until 2002, and Sanders retired in 1998.
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Emmitt Smith
http://www.pro-football-reference.com/players/S/SmitEm00.htm?redir
18355 Career Yards
In the NFL the stat of all purpose yards usually refers to the yards obtained during a game, season, or career by a running back or a receiver. The yards referred to are both gained by receiving and rushing. Normally a running back will have the most all purpose yards, because receivers do not usually run the ball as often as runners catch the ball. Due to the formations in the NFL this can be achieved.
For a career that is Michael Vick with 7.1 yards per rushing attempt (through 10 games of the 2010 season). Most of the career leaders in this category are quarterbacks. The running back with the highest yards per rushing attempt is Marion Motley at 5.7. For a single season, the record is held by Vick of the 2006 Falcons and running back Beattie Feathers of the 1934 Bears with 8.4 yards per rushing attempt.
In a career, Randall Cunningham holds the record for rushing yards by a Quarterback with 4928. Michael Vick does hold the single season record with 1039 yards.
The Caucasian with the most rushing yards is John Riggins with 11,352 yards 16th on the all time list. He played from 1971-1985 with the New York Jets and Washington Redskins.
In the NFL, 231 against the Colts on September 12, 2010.