Dallas Cowboys/ Arizona Cardinals Emmitt Smith w/ 18,000+ yards.
Curtis Martin
Emmitt Smith, with 18,355 career rushing yards.
Yes, in the NFL, negative rushing yards are subtracted from a running back's total rushing yards. If a running back loses yards on a carry, those negative yards are counted against their overall rushing total for that game and season. This means that a player's rushing yards reflect both positive and negative yardage from their carries.
Franco Harris (11,950)Jerome Bettis (10,571)
For a career that is Michael Vick with 7.1 yards per rushing attempt (through 10 games of the 2010 season). Most of the career leaders in this category are quarterbacks. The running back with the highest yards per rushing attempt is Marion Motley at 5.7. For a single season, the record is held by Vick of the 2006 Falcons and running back Beattie Feathers of the 1934 Bears with 8.4 yards per rushing attempt.
Frank Gore with 110 rushing yards.
Terrell Davis of the Denver Broncos had the most rushing yards in 1998. He had 2008 yards and was the fourth running back in NFL history to rush for over 2000 yards.
Joseph Addai of the Colts who had 77 rushing yards
Jim Brown of the Cleveland Browns. Brown played in 118 games and gained 12,312 rushing yards for an average of 104.3 rushing yards per game.
LaDainian Tomlinson
Clem Daniels
Barry Sanders