Jake Plummer, QB for the Arizona Cardinals and Denver Broncos between 1997 and 2006, holds the record for most career tackles by a QB with 20. Statistics are available starting in 1994.
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When the defense tackles the quarterback behind the line of scrimmage for a loss.
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Inside Linebacker Patrick Willis of the San Francisco 49ers led the NFL in tackles. He racked up 174 tackles in 2007.