Paul Krause with 81.
Krause played safety for the Redskins and Vikings between 1964-1979.
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Through the 2008 season in the NFL, that is Brett Favre with 310 career interceptions.
The NFL player with the most career interceptions (81) is Paul Krause, who played for Washington and Minnesota in the 1960s and 70s. He had a 15-year career in the NFL.
Paul Krause who played for the Minnesota Vikings. He had 81 interceptions for his career.
Brett Favre - 366 interceptions in his career, regular season and playoffs.
brett farve