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In the NFL, the record for interceptions in a season is 14 by Dick 'Night Train' Lane of the Los Angeles Rams in 1952.
The quarterback that has the most interceptions is Brett Favre, he has 22 interceptions
the other team
Brett Favre - 366 interceptions in his career, regular season and playoffs.
Through the 2008 season in the NFL, that is Brett Favre with 310 career interceptions.