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There is no way to tell the exact average, but there is usually 1 starter for each team, a relief pitcher, and the closer. So about 6 total. -----The number of pitches would depend on many factors, but usually there is a minimum of at least 200 pitches in a game. High scoring games or those with a lot of walks could approach or even pass 300 pitches.
Pitchers in MLB and the minor leagues get eight warmup pitches when entering a game unless they are entering the game due to an injury to the previous pitcher. If the previous pitcher was injured the relieving pitcher may take as many warmup pitches as the umpire deems necessary. Rule 8.03
I believe that almost every pitcher who has pitched for more than 30 innings has struck out someone in three pitches. It isn't very hard for a pitcher to strike someone out in three pitches, especially if they have pitched for 30 innings.
26 pitches to Roy Thomas he fouled off 22 pitches 3 were balls and then the one he put in play
Click on the links under the 'Related Questions' heading at the bottom of this page for instructions on throwing the pitches an MLB pitcher throws.