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Tyson's first professional loss was to Buster Douglas for the IBF/WBA/WBC heavyweight titles in 1990.

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Wiki User

16y ago

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More answers

hector mercedes, in march 1985. http://www.boxrec.com/list_bouts.php?human_id=474&cat=boxer

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Wiki User

15y ago
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He lost to James 'Buster' Douglas in February 2nd 1990.

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Wiki User

13y ago
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Holyfield

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Anonymous

4y ago
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Q: Who was Mike Tyson first professional fight against?
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