2018-(16)U.M.B.C
1991-(15)Richmond, 1993-(15)Santa Clara, 1997-(15)Coppin State, 2001-(15)Hampton, 2012-(15)Norfolk State, (15)Lehigh, 2013-(15)Florida-Gulf Coast (made it to Sweet 16), 2016-(15)Middle Tennessee
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The lowest seed to ever win a NCAA Basketball title was Villanova, ranked seed #8. They won the tournament in 1985.
Lower seeds have made it to the Final Four (George Mason and Louisiana State, ranked 11th, made it in 2006 and 1986 respectively) but never won.
UCLA in 1980 was ranked 48th and made it to the championship game.
no. 8 Villanova beat Georgetown in 1985 UCLA made the championship game in 1980 as an 8 seed, but lost to Louisville.