Value is based on average prices of recently closed auctions. Prices may vary based on condition, and the type of authenticity that accompanies the baseball. Signatures that have not been properly authenticated could sell at half the market value or less. Add for inscriptions.
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Nolan Ryan did not play for the Astros until 1980 so I'm not sure what card you have but it doesn't make much of a difference unless it is a card like his 1968 rookie card. In that case the signature will lower the value of the card. In general, collectors of baseball cards would rather have a baseball card without the signature. The signature would be considered as a flaw in the condition of the card and will lower the value. If the signature has a lower value than the card it will lower the value of the card. The un-signed card will have a higher value.