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Brett Favre has been injured, but he has never missed a NFL game in his career.
No!
Injured reserve list
An NFL team has 53 men on its roster not counting injured reserve.
all
A player on injured reserve remains on the team but cannot participate on the active roster for the remainder of the season.
how many players get injured in a year in professional football
they workout with the player, medically help the players if injured
for about 4 years
New york giants
In 2010, around 300 players wound up injured badly enough they went on injured reserve.
how does IR for an NFL player affect his salary