As of 2007, Emmitt Smith holds the record for 18,400 rushing yards. He also holds the record for the most rushing touchdowns with 164. Second place is Ladainian Tomlinson with about 120.
Emmitt Smith 18,355 rushing yards
Barry Sanders retired with the Lions' rushing record in 1999.
Emmit Smith..18,355 yards..........loved the guy
Emmitt Smith with 18,355 career yards.
In a career, Randall Cunningham holds the record for rushing yards by a Quarterback with 4928. Michael Vick does hold the single season record with 1039 yards.