As of 2007, Emmitt Smith holds the record for 18,400 rushing yards. He also holds the record for the most rushing touchdowns with 164. Second place is Ladainian Tomlinson with about 120.
Barry Sanders retired with the Lions' rushing record in 1999.
In a career, Randall Cunningham holds the record for rushing yards by a Quarterback with 4928. Michael Vick does hold the single season record with 1039 yards.
As of the start of the 2007 season, Walter Payton has the second most career rushing yards in NFL history with 16,726. Emmitt Smith is first with 18,355 and Barry Sanders is third with 15,269.