Ken Caminiti of the Astros in the 8th inning of Game 4 of the 1999 NLDS off John Smoltz of the Atlanta Braves.
Willie Mays. Mays hit his 500th home run at the Astrodome on September 13, 1965.
Yes, he hit 13 regular season home runs in the Astrodome. The first came on May 30, 1965 off of Larry Dierker and the last came April 21, 1974 off of Tom Griffin.
On April 9, 1965, Mickey Mantle hit the first home run in the Houston Astrodome, off pitcher Turk Farrell.
Wilie Stargell had 475 career home runs.
The very first home run ever hit in the Astrodome was hit on opening day, April 15, 1965 by Dick Allen, off Bob Bruce. Box score: http://www.baseball-reference.com/boxes/HOU/HOU196504120.shtml
He was forty-years-old when he hit his last home run
Derek Jeter's last home run was on May 8, 2011. He hit two in that game.
Jose Molina hit the last home run at the old Yankee Stadium in the 4th inning. Johnny Damon hit the second to last home run in the third inning.
Babe Ruth hit his last home run in 1935 for the Boston Braves.
Your mom hit the home run last night in bed
Jim Thome.
New York Yankees catcher Duke Sims hit the last home run at Yankees Stadium in 1973. The home run was hit on the last game of the season played on September 30, in the bottom of the 7th inning, off Detroit Tigers pitcher Fred Holdsworth. This was the last home run in Yankees stadium before the renovation.