Manning
Peyton has more in his career with 64,964 yards compared to Brady's 49,149. While Manning has been in the league two years longer than Brady, Peyton would almost certainly still have more yards
Tom Brady, Peyton Manning, and Drew Brees
Drew Brees[ Saints QB]
Peyton Manning
Among active players it is Peyton Manning but among inactive it is Dan Marino
Drew Brees and Peyton Manning
Peyton Manning was 31-45 for 333 yards compared to Drew Brees' 32-39 for 288 yards.
346 yards according to Yahoo sports
Colts QB Peyton Manning had 31 of 45 passes completed for 333 yards, 1 TD, and 1 interception.
In the NFL through the 2009 regular season, that is 472 yards (Manning threw for 5 TDs) against the Kansas City Chiefs on October 31, 2004. The Chiefs won that game 45-35.
Tom Brady has 39, 979 passing yards and Tony Romo has 20,834 passing yards. So Tom Brady has more
54,828 yards as of week 17 of the 2010 season.