The first train of the day, you mean? If so, then, shortly after midnight. The New York City subway system runs 24 hours a day, 365 days a year, so there is no "first" train of the day. The first train of the day is the first one that comes after midnight.
Take the Uptown A or C (of the A-C-E, the blue line) from 34th Street-Penn Station to 59th Street-Columbus Circle. At 59th Street-Columbus Circle, transfer to the Uptown B or D trains. Take the Uptown B or D to 161st Street-Yankee Stadium.The Bronx-bound D train does not stop at Yankee Stadium on weekdays from 4 to 6:45 PM, so if you are traveling during those times, you need to take the B.Don't take the B unless you are traveling on a weekday between 4 and 6:45 PM, because the B only stops at Yankee Stadium when the D isn't stopping there.
Assuming you are asking for subway directions: take the Downtown B or D trains (of the B-D-F-M, the orange line) from 161st Street-Yankee Stadium to 47th-50th Street-Rockefeller Center (at 6th Avenue).At 47th to 50th Street, 7th Avenue is the next block west of 6th, and the next block west of 7th is Broadway. Below 44th to 45th Street, the next block west of 6th is Broadway, then 7th. This is because Broadway runs diagonally through Manhattan, veering increasingly east as it moves south.The Theatre District consists of Broadway and 7th Avenue, from 40th or 41st Street to 53rd or 54th Street.
If you are traveling at any time EXCEPT weekdays between 4 and 6:45 PM:Take the Uptown B train (of the B-D-F-M, the orange line) or Uptown C train (of the A-C-E, the blue line) from 72nd Street (at Central Park West) to 125th Street or 145th Street.Transfer at 125th or 145th to the Uptown D train to 161st Street-Yankee Stadium.If you are traveling on a weekday between 4 and 6:45 PM:Take the Uptown B train from 72nd Street to 161st Street-Yankee Stadium.The B train only stops at Yankee Stadium during morning and evening rush hours in peak directions, when the D isn't stopping there. The Downtown (Manhattan-bound) Dskips the 161st Street-Yankee Stadium stop from 6:15 to 9 AM on weekdays, and the Uptown (Bronx-bound) D skips the Yankee Stadium stop from 4 to 6:45 PM on weekdays.
At a local or national Destination
First you need to take the shuttle, the AirTrain, from the JFK terminals to the Howard Beach Station of the A train (of the A-C-E, the blue line).Take the Manhattan-bound A train from Howard Beach to 59th Street-Columbus Circle.Transfer at 59th Street-Columbus Circle to the Uptown Bor D trains (of the B-D-F-M, the orange line) to 161st Street-Yankee Stadium (in the Bronx).Note that the B does not run on the weekends. Also, on weekdays, the B only runs as far Uptown as 145th Street in Manhattan, except during rush hours (6 to 9:30 AM and 4 to 7 PM), when the D isn't running in the peak directions.In rush hours in peak directions (6:15 to 9 AM heading into Manhattan, and 4 to 6:45 PM heading from Manhattan) the Ddoesn't stop at Yankee Stadium.So, you will need to take the D from 59th Street-Columbus Circle to 161st Street-Yankee Stadium, UNLESS you are traveling on a weekday, between 4 and 6:45 PM, in which case you need to take the B.
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The simplest way would be to take the Downtown B or D trains (of the B-D-F-M, the orange line) from 161st Street-Yankee Stadium to 59th Street-Columbus Circle, which is at the southwest corner of the park.If you want to get off at the middle or north end of the park, you can take the B. It is a local train and makes 7 stops along 8th Avenue/Central Park West (the portion of 8th Avenue that borders the park is called Central Park West), from 110th Street/Central Park North to 59th Street/Central Park South. The D is an express train and goes straight from 125th Street to 59th Street.However, the B only stops at Yankee Stadium from 6 to 9:30 AM on weekdays, when the D does not stop there. So, if you want to get off at the middle or north end of the park, but you're not traveling on a weekday between 6 and 9:30 AM, then you'll have to take a slightly different route.Instead, take the Downtown D to 125th Street, and transfer there to the Downtown B. You can get off the B on Central Park West at: 110th Street-Cathedral Parkway, 103rd Street, 96th Street, 86th Street, 81st Street-Museum of Natural History, 72nd Street and 59th Street-Columbus Circle.
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Virgin Trains services between London Euston and Liverpool Lime Street.
They both travel on tracks.