Take the Uptown A or C (of the A-C-E, the blue line) from 34th Street-Penn Station to 59th Street-Columbus Circle. At 59th Street-Columbus Circle, transfer to the Uptown B or D trains. Take the Uptown B or D to 161st Street-Yankee Stadium.
The Bronx-bound D train does not stop at Yankee Stadium on weekdays from 4 to 6:45 PM, so if you are traveling during those times, you need to take the B.
Don't take the B unless you are traveling on a weekday between 4 and 6:45 PM, because the B only stops at Yankee Stadium when the D isn't stopping there.
45 minutes
The trip lasts about 45 minutes.
No, the AirTrain takes you to and from the subway, and the subway takes you to and from Penn Station. Take the AirTrain to the Howard Beach Station, and get the Manhattan-bound A train (of the A-C-E, the blue line) to 34th Street-Penn Station.
No. You would have to transfer at another station that has access to it.
No, but it does stop at penn station and you can take the subway
Take the Uptown E train (of the A-C-E, the blue line) from 34th Street-Penn Station to Court Square.
MetroNorth from Poughkeepsie goes to Grand Central. Amtrak from Poughkeepsie goes to Penn STation. It's very easy to take MetroNOrth to Grand Central and then get the subway to Penn Station.
You don't need to take the subway to get from Penn Station to 28th Street and 8th Avenue (which is in the Chelsea neighborhood, by the way, not in Greenwich Village or Greenwich Connecticut). Penn Station is at 34th Street between 8th and 7th Avenues. So you can just walk there.
E-train north.
The 1, 2, and 3 trains go from Times Square to Penn Station. The A, C, and E trains run parallel, going from Port Authority to Penn Station. However, the Port Authority Station and the Times Square Station are connected underground.
You don't have to take the subway; it's 2 blocks. Penn Station is at 34th Street between 8th and 7th Avenues, and 520 8th Avenue is between 36th and 37th Streets.
Take the Uptown 1-2-3 (the red line) from 34th Street-Penn Station to 42nd Street-Times Square, and transfer there to the N.