For a single game it is 578 yards.
Chris Johnson set NCAA FBS record of 408 all-purpose yards
Barry Sanders for Oklahoma St. in 1988 with 3250 all purpose yards.
Damaris Johnson of Tulsa
Eddie Podolak Eddie Podolak
DeAngelo Williams (7,535). he also holds the record for most 100-yard rushing games for a career with 34The record was actually broken this weekend. Brandon West of the Western Michigan Broncos set the new record (7,626) with one game remaining in the season.
The University of Oklahoma. In 1971 the Oklahoma Sooners offense led the nation in both scoring (45 points average) and total yards (563 total yards average), and set a NCAA record by averaging over 472 rushing yards per game. A record that still stands.
LaDainian Tomlinson holds the NCAA single-game rushing record with 406 yards for Texas Christian against Texas El Paso in 1999. I'm an alum of TCU, and I believe that this record still holds strong. That record has long since be broken, last year in fact a kid from Southern Connecticut State university, Jarom Freeman rush for 418 yards. Forth most in NCAA history.
Ricky Williams holds the 1-A rushing record for the ncaa at 6.138 yards from the University of Texas. Ron Dayne from the University of Wisconsin holds the D1A career rushing record with 6,397 yards between 1996-1999.