In 2007 the Baltimore Orioles lost at home to the Texas Rangers, 30-3. 27 runs is the biggest run differential in a single regular-season Major League Baseball game.
the new york mets
Yankees Yankees
The Carolina Panthers.
By scoring the most runs in nine innings
13
florida gators
Philadephia Phillies
The Chicago White Sox led the majors in Home Runs with 235.
123
As of September 16, the Milwaukee Brewers have the most losses by one run with 29.
Joe Bauman
Not the team that lost