Five. It happened twice, in a 44-30 loss to the NY Jets in 1988 and a 20-0 shutout by the Dallas Cowboys in 1999.
George Blanda from the Houston threw 42 interceptions in 1962
Rich Gannon threw 5 interceptions in the 2002 Super bowl. He was on the Raiders.
Jim hardy of the cardinals threw 8 interceptions in a game in the 1950's
Jim Hardy of the Chicago threw 8 interceptions in a 1950 game. More recently, Ty Detmer of the Detroit Lions threw 7 interceptions against the Cleveland Browns in week 1 of the 2001 season.
In 2010, Eli Manning of the New York Giants threw the most interceptions with 25.
Brett Favre - 366 interceptions in his career, regular season and playoffs.
Most Interceptions ThrownGeorge Blanda (Houston Oilers '62) threw the most interceptions in one season.
Jim hardy threw 8 in 1950 for the Chicago cardinals (now Arizona)