Since interleague play began in 1997, the St. Louis Cardinals and the Chicago White Sox have played 18 times. The Cardinals have won 10 of the games.
The Chicago White Sox, after the 2006 interleague play. Oakland had it going into this year.
as of the 2010 season, the White Sox lead the all time record (since interleague play began) with 37 wins to the Cubs 35 wins. The White Sox won the Interleague Series against the Cubs in 2010 by 4 games-to-2 so after the 2010 season, the White Sox lead in the series 41 Wins to 37 wins
Red Sox
The White Sox record in the 2007 season was 72-90.
That was the St. Louis Cardinals at 100-62. In the American League, the Chicago White Sox had the best regular season record at 99-63.
In 2006, the Chicago White Sox had a 90-72 record.
In 2008, the Chicago White Sox had an 89-74 record.
2989 hits
100-54
Since interleague play began in 1997, the two Chicago teams have played 93 times, with the White Sox holding a 49-44 edge over the Cubs. In 2014, the White Sox won three out of four games -- a two-game sweep of the Cubs at Wrigley Field, while managing a split at U.S. Cellular Field.
In 2012, the Chicago White Sox had an 85-67 record.
In 2000, the Chicago White Sox had a 95-67 record.