as of the 2010 season, the White Sox lead the all time record (since interleague play began) with 37 wins to the Cubs 35 wins.
The White Sox won the Interleague Series against the Cubs in 2010 by 4 games-to-2 so after the 2010 season, the White Sox lead in the series 41 Wins to 37 wins
Yes, American League teams play against National League teams in interleague games during the regular season.
Yes, the American League and the National League teams play against each other in Major League Baseball during interleague play and the World Series.
Yes, American League and National League teams play against each other in interleague games during the regular season.
Interleague is referring to within the league. If someone is playing an interleague team, they are playing someone in the same league as them.
The Chicago White Sox compete in Major League Baseball's American League Central Division. Their primary rivals include the Minnesota Twins, Cleveland Guardians, and Detroit Tigers. Additionally, they face teams from the American League East and West, as well as interleague matchups against National League teams. The White Sox also have a historic rivalry with the Chicago Cubs, known as the Crosstown Classic.
Regular season baseball games between the American League and National League are called interleague games. The first interleague games occurred in 1998 and have been a staple of the MLB schedule since. In 2013 the leagues were balanced to have 15 teams each (the Houston Astros switched from the National League to the American League) which necessitated interleague games throughout the season. Before 2013 interleague games typically happened in concentrated pockets during June and July.
Since interleague play began in 1997, the Cubs have played all of the other 29 teams.
Yes, Illiniois has 2 Major League Baseball teams, the Chicago White Sox in the American League and the Chicago Cubs in the National League.
The Chicago White Sox play in the American League.
The Chicago Cubs are the National League team, and the Chicago White Sox are the American League team.
Interleague play began in 1997.
The Chicago Cubs