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Although he played division III, his record is so outstanding I think it is a good answer to this question. The best I can find is Bill Borchert, the QB at Mt. Union from 1994 thru 1997. His career TD/Int ratio was 141/17. His best season was 1997, at 47/1.

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Q: What is the all-time best touchdown to interception ratio for a quarterback in one season and over a career?
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