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The most pitchers used in one major league game was a combination of the two teams of the St. Louis Cardinals and the Pittsburgh Pirates on September 30th 2007. The St. Louis Cardinals also set a major league record that day using 10 pitchers in one game while the Pirates used 8. -Tibbs

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โˆ™ 2007-10-22 02:48:13
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Q: What are the most pitchers used in one baseball game?
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