At the time of this question, Mark Buehrle had the most strikeouts, but currently Freddy Garcia does.
Jack McDowell
Roger Clemens- 20, two times: '96 Detroit '86 Seattle
Mark Buehrle
Pedro Martinez. Martinez holds the Red Sox single season strikeout record with 313 in 1999.
Season: Ed Walsh of the 1908 White Sox with 40. Career: Ted Lyons with 260 between 1923-1942 and 1946.
BiG Ed Walsh ~ Chicago White Sox ~ 41 games
Mark Bellhorn with 177 in 2004.
The MLB record for strikeouts in a doubleheader is 7 and is held by six players ... Pat Seerey of the Chicago White Sox in 1948, Dave Nicholson of the White Sox in 1963, Frank Howard of the Washington Senators in 1965, Bill Melton of the White Sox in 1970, Mike Vail of the New York Mets in 1975, and Shea Hillenbrand of the Toronto Blue Jays in 2005.
The cast of 2005 World Series - 2005 includes: Ezequiel Astacio as Himself - Houston Astros Pitcher Brad Ausmus as Himself - Houston Astros Catcher Jeff Bagwell as Himself - Houston Astros Pinch Hitter Craig Biggio as Himself - Houston Astros Second Baseman Geoff Blum as Himself - Chicago White Sox Second Baseman Mark Buehrle as Himself - Chicago White Sox Pitcher Neal Cotts as Himself - Chicago White Sox Pitcher Joe Crede as Himself - Chicago White Sox Third Baseman Jermaine Dye as Himself - Chicago White Sox Right Fielder Morgan Ensberg as Himself - Houston Astros Third Baseman Carl Everett as Himself - Chicago White Sox Pinch Hitter Adam Everett as Himself - Houston Astros Shortstop Mike Gallo as Himself - Houston Astros Pitcher Jon Garland as Himself - Chicago White Sox Pitcher Ozzie Guillen as Himself - Chicago White Sox Manager Dustin Hermanson as Himself - Chicago White Sox Pitcher Tadahito Iguchi as Himself - Chicago White Sox Second Baseman Bobby Jenks as Himself - Chicago White Sox Pitcher Paul Konerko as Himself - Chicago White Sox First Baseman Brad Lidge as Himself - Houston Astros Pitcher Damaso Marte as Himself - Chicago White Sox Pitcher Tim McCarver as Himself - Color Commentator Chris Myers as Himself - Field Reporter Roy Oswalt as Himself - Houston Astros Pitcher Timo Perez as Himself - Chicago White Sox Pinch Hitter Scott Podsednik as Himself - Chicago White Sox Left Fielder Cliff Politte as Himself - Chicago White Sox Pitcher Chad Qualls as Himself - Houston Astros Pitcher Wandy Rodriguez as Himself - Houston Astros Pitcher Aaron Rowand as Himself - Chicago White Sox Center Fielder Russ Springer as Himself - Houston Astros Pitcher Willy Taveras as Himself - Houston Astros Center Fielder Luis Vizcaino as Himself - Chicago White Sox Pitcher Chris Widger as Himself - Chicago White Sox Catcher Jeanne Zelasko as Herself - Pregame Host
Roger Clemens
Estaban Louiza
Mark Buehrle