No it's single player only.
He is one of five players to berak 2,000 yards in a single season.
In MLB you may use your entire roster in a single game, however, once a player is removed from the game he may not return.
Jason Giambi, Jose Bautista, Carlos Beltran, Edwin Encarnacion. Those players for sure.
brady Anderson, barry bonds
4800 single players in the NFL, i think...