No. The origins of both the American League and National League are from years before 1905... The National League of Baseball freanchises (and MLB in general) originated in the late 1800's while the American League of Professional Baseball Franchises was founded in 1901. The first major league game was played May 4, 1871 between the Cleveland Forest Cities and the Fort Wayne Kekiongas. Click on the 'FIrst MLB Game' link on this page to read about it.
The first Major League perfect game was pitched by Lee Richmond on June 12, 1880.
The first Major League All-Star Game was played at Comiskey Park in Chicago, Illinois. The date was July 6, 1933 and the American League was the winner.
No regular season Major League baseball game has ever been played in Spain.
Although the definition of "major league" has been argued, present day MLB, as well as the Hall of Fame, define the first "major" league as the National League founded in 1876. The link below describes the first game played in that league, on April 22, and mentions that Jim O'Rourke got the first hit in that game.
The first person to throw a pitch in a major league baseball game was Bobby Mathews of the Fort Wayne Kekiongas against the Cleveland Forest Cities on May 4, 1871. The first batter in a major league game, Deacon White, hit a double. I don't know if it was on the first pitch, though.
major league managers who never played in a major league game
Mickey Mantle hit first home run at Astrodome during preseason game with the Yankees and Astros.......
Emmett Ashford is the first black umpire in a major league game when Cleveland beats Washington
Starlin Castro had six RBI in his Major League debut in 2010 for the Chicago Cubs.
Fort Wayne, Indiana
1935 at Crosley Field in Cincinnati
Bumpus Jones of the Cincinnati Reds threw a no hitter on October 15, 1892 in his first major league game.
Benjamin Harrison, the 23rd President of the U.S., was the first president to go to a Major League baseball game. He was president from 1889 to 1893. Harrison had previously served as a Senator from Indiana.
Major League Baseball Game of the Week was created in 1996.
The inaugural game was held in 1933.