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It has happened 18 times in the history of Major League Baseball. The last time was on July 21, 2012, when starting pitchers Matt Cain of the San Francisco Giants and Cole Hamels of the Philadelphia Phillies hit home runs off each other. They both homered in the third inning of the game played at Philadelphia's Citizens Bank Park. Cain hit his sixth career homer -- a solo shot -- in the top of the inning. In the bottom half, Hamels blasted his first-ever major league homer, also with the bases empty. The Giants won the game in 10 innings, 6-5.

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