The earliest round for a 1 seed to go out in the NCAA basketball tourney is in the first round. It happened in 2018 when the University of Maryland - Baltimore County (16th seed in the South) beat the University of Virginia (1st seed in the South) by a score of 74 - 54.
Villanova was an eighth seed in 1985.
No, not yet.
UNC was a number 1 seed in the 2009 NCAA basketball tournament.
1 seed
Wake Forest was a number 4 seed in the 2009 NCAA Basketball Tournament.
The Kansas Jayhawks
A 4 seed.
Since the NCAA implemented the 64 seed tournament format in 1985, the lowest seed to make it to the NCAA championship game was #8 seeded Villanova in 1985.
Michigan was a #3 seed when they won the NCAA Men's Basketball Tournament in 1989.
12
Yes a number 16 seed has beat a number one seed in the NCAA basketball tournament, but it was in the womens' tournament. In 1988, 16th seed Harvard beat 1st seed Stanford in the womens' tourney. (Answer by Mymomisnfat) It also happened in 2018 when the University of Maryland - Baltimore County (16th seed in the South) beat the University of Virginia (1st seed in the South) by a score of 74 - 54.