No, because he was traded to the Mets for some rookie prospects, including Carlos Gomez.
Yes, quite a few times with the Twins.
Johan Santana, Minnesota Twins
Johan Santana, Minnesota Twins
Johan Santana in 2006.
Johan Santana of the Twins
Johan Santana with 265 strikeouts in 2004.
Johan Santana of the Minnesota Twins with 238.
Johan Santana debuted on April 3, 2000, playing for the Minnesota Twins at Hubert H Humphrey Metrodome; he played his final game on August 17, 2012, playing for the New York Mets at Citi Field.
In MLB, that was September 5, 2003 off of Johan Santana of the Minnesota Twins.
Danny Santana is number 39 on the Minnesota Twins.
In 2000, Johan Santana played in 30 games, all for the Minnesota Twins, and batting in 2 of them. He had 1 at bat, getting 0 hits, for a .000 batting average, with 0 runs batted in. He was walked 0 times. He struck out 0 times.
In 2006, Johan Santana played in 34 games, all for the Minnesota Twins, and batting in 1 of them. He had 2 at bats, getting 0 hits, for a .000 batting average, with 0 runs batted in. He was walked 0 times. He struck out 2 times.