The river that is known as the Gateway to the West is the Missouri River. It flows into the Mississippi River at St. Louis, MO.
Mississippi, in the US
the ohio river
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The Ohio River.
St. Louis, MO
Miami, FL
Rochester is known as the gateway to the Finger Lakes and is the state's third-largest city, behind New York City and Buffalo. It is also stated to be the best place to live in the US.
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It was the starting point. The gateway to the west. The US ended at the banks of the Missouri River.
Ozette, Washington is the westernmost city in the continental US.
Key West - the southernmost city in the US - is located in Florida.
A major US city due west of Milwaukee, Wisconsin is Madison, Wisconsin.