Worst loss in Yankees history

Answer 1

Probably Game 7 of the 1960 World Series, in which the Pittsburgh Pirates' Bill Mazeroski hit a series-ending home run for the Pirates. The Pirates had been outscored and outslugged by the Yankees, who won three games by the runaway scores of 16-3, 10-0 and 12-0. The Pirates fought back with three close wins by the scores of 6-4, 3-2 and 5-2.

Game 7 at Pittsburgh's Forbes Field was tied 9-9 when Mazeroski hit his walk-off homer off New York's Ralph Terry for a 10-9 victory.

Answer 2

August 31, 2004 the Cleveland Indians beat the Yankees 22-0. Go Tribe! :)