Manning wore No. 18 In honor of his older brother Cooper, who could not continue playing football in college because of a congenitive spinal problem. Cooper wore 18 at Isidore Newman High School in New Orleans, and was Peyton's favorite receiver when they played there together.
Their father, Archie Manning, wore No. 18 at the University of Mississippi from 1968 to 1970.
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Because his brother cooper wore number 18 in high school, and was diagnosed with a disease that prevented him from playing in college, let alone pro. Peyton wears 18 in honor of cooper.
Punt returner Nate Jacquet, who was drafted by the Colts in 1997 but played only five games for them before going to the Miami Dolphins.
At present the most prominent player to wear #18 is Indianapolis Colts quarterback Peyton Manning.