1. Adrian Peterson of the Minnesota Vikings. November 4, 2007 against the San Diego Chargers he racked up 296 rush yards.
2. Jamal Lewis of the Baltimore Ravens. September 14, 2003 against the Cleveland Browns he totaled 295 yards.
3. Jerome Harrison of the Cleveland Browns. December 20, 2009 in Kansas City against the Chiefs he ran for 286 yards and three touchdowns.
4. Corey Dillon of the Cincinnati Bengals. October 22, 2000 against the Denver Broncos he rushed for a total of 278 yards.
5. Walter Payton of the Chicago Bears. November 20, 1977 against the Minnesota Vikings he ran for 275 yards.
6. Orenthal James (O.J.) Simpson of the Buffalo Bills. November 25, 1976 against the Detroit Lions he managed to gain a total of 273 yards.
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