The NFL record for penalties in a game by a team is 22 and is held by three teams: 1) Brooklyn Dodgers in a game against the Packers in 1944.
2) Chicago Bears in a game against the Eagles in 1944.
3) San Francisco 49ers in a game against the Bills in 1998.
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The record for the most penalties, both teams, in one game is 37, set by Cleveland (21 penalties, 209 yards) and Chicago (16 penalties, 165 yards) on November 25, 1951. Naturally, that game also set the record for the most yards penalized. The final score was Chicago 21, Cleveland 42. In that game, Dub Jones scored six touchdowns for the Browns (a record tied by Gale Sayers in 1965, but never surpassed).
In one series of downs, the Browns' defense was charged three times with personal fouls and penalized 15 yards, each time. The three penalties put the Bears on Cleveland's 9 yard line, but they still couldn't score.
The record for most turnovers in an NCAA football game is 13. This statistic was achieved by Georgia Tech against Georgia in 1951 when they had 5 fumbles and 8 interceptions.